新发糖尿病——胰腺癌早期筛查和诊断的临床线索

Clinical clues to early screening and diagnosis of new- onset diabetes as an early sign of pancreatic cancer

摘要:

胰腺癌是一种高度恶性的消化系统恶性肿瘤, 因其起病隐匿、缺乏有效特异的早期筛查手段，发现时多为晚期，已失去手术时机，预后很差。糖尿病是胰腺癌发生的危险因素，新发糖尿病可能是胰腺癌的病因或早期表现之一,有助于胰腺癌的早期发现与诊断；而不同降糖药物的应用可能对胰腺癌的发生具有一定影响。在糖尿病患者中发现胰腺癌的特异性血清微小RNA（microRNA），可能成为未来胰腺癌早期筛查和预后监测的非侵入性生物标志物。

Abstract:

Pancreatic cancer (PC), a highly malignant tumor of digestive system, is often diagnosed in the late stage and usually too late for surgical treatment because of its insidious onset and lack of effective specific screening techniques in early stage, and thus has very poor prognosis. Diabetes is a risk factor for PC. The new- onset diabetes could be one of the reasons or early manifestations of PC, and probably help its early detection and diagnosis. However, various hypoglycemic agents may have certain influence on the occurrence of PC. Specific serum microRNAs (miRNA) of PC in diabetes patients could probably be considered as non- invasive biomarkers for early screening and prognosis monitoring of PC.