糖耐量减低患者记忆及相关脑区激活改变的探讨

Memory function and related brain area activation in patients with impaired glucose tolerance

摘要:

目的 探讨并分析糖耐量减低（IGT）中年患者与糖耐量正常（NGT）受试者的记忆功能及工作记忆任务下的脑区激活改变。方法 对13例IGT患者和19名NGT受试者进行相关实验室检查、记忆评估和工作记忆任务下的功能性磁共振检查，比较两组间记忆功能及脑激活图。结果 IGT患者的视觉再生、触觉、理解等短时记忆功能较NGT受试者减低，差异有统计学意义（P<0.05）；IGT患者右侧颞叶、颞上回（brodmann area22,BA22区）、豆状核、壳核、尾状核体激活较NGT受试者减弱。结论 IGT患者可能存在早期短时记忆功能障碍，与相关脑区激活的减弱有关。

Abstract:

Objective To investigate the memory function and related brain activation during a working memory in the patients with impaired glucose tolerance (IGT) and the subjects with normal glucose tolerance (NGT). Methods Laboratory examination, memory evaluation and functional magnetic resonance imaging (fMRI) during a working memory were performed in 13 IGT patients and 19 NGT subjects. Memory function and related laboratory results were analyzed and compared between the 2 groups. Results The vision regeneration, sense of touch, understanding and other short- term memory functions were significantly reduced in the IGT patients than in NGT subjects(P<0.05). The activations in brain areas of the right temporal lobe, back temporal (brodmann area 22, BA22 region), lenticular nucleus, putamen and caudate nucleus were weakened in the IGT patients than in the NGT subjects. ConclusionIGT patients may exist early short- term memory dysfunction, which may be related with weakened activation in brain regions.