糖尿病周围神经病变生物学标志物的临床研究进展

Advances in biomarkers for diabetic peripheral neuropathy

摘要:

糖尿病周围神经病变（DPN）是糖尿病最常见的慢性并发症之一，可导致足部溃疡、坏疽，甚至截肢，对患者的生活质量造成极大影响。DPN的发病机制复杂。近年来，针对DPN发病各个环节的生物学标志物的研究取得了一定进展。本文以DPN的病理生理改变及发病机制为出发点，主要从神经组织损伤、内皮功能紊乱、氧化应激和炎症4个方面综述DPN的潜在生物学标志物。

Abstract:

Diabetic peripheral neuropathy (DPN), one of the most common chronic complications of diabetes, can lead to foot ulceration, gangrene, and even limb amputation, and impose great impact on patients’ quality of life. Its pathogenetic mechanism is very complicated. In recent years, certain advances have been taken in identifying biomarkers at different stages in the pathogenesis of DPN. This review summarized the potential blood biomarkers of DPN from the aspects of nerve injury, endothelial dysfunction, oxidative stress as well as inflammation based on the pathology and pathogenesis of DPN.