钠离子通道与慢性心力衰竭

Sodium channel and chronic heart failure

摘要:

钠离子通道能产生对心肌细胞动作电位发生和传播起重要作用的快钠电流，还能产生影响动作电位时程的晚钠电流（INaL）。钠离子通道功能的改变是多种心血管疾病的发病基础，心血管疾病发生后也会产生钠离子通道重构。慢性心力衰竭（HF）是临床常见的心血管病综合征，钠离子通道，特别是INaL与慢性HF的研究已成为近期的热点，本文就钠离子通道与慢性HF的相互关系进行了综述。

Abstract:

Sodium channel can produce fast sodium current which is important for the occurrence and propagation of cardiac action potential, and also produce late sodium current (INaL) which contributes to action potential duration. Functional changes of sodium channel act as substrate for many cardiac diseases, and sodium channel may be remodeled in response to cardiac disease. Chronic heart failure (HF) is a common cardiac syndrome clinically. Sodium channel, especially concerning INaL and chronic HF, has become a hotspot in recent studies. We reviewed the relationship between the sodium channel and chronic HF in this article.