老年患者嗜酸细胞肉芽肿性血管炎的临床特征

Clinical features of eosinophilic granulomatosis with polyangiitis in the elderly

摘要:

嗜酸细胞肉芽肿性血管炎（EGPA）是以外周血和受累脏器组织中嗜酸性粒细胞增高并伴有坏死性肉芽肿为特征的系统性血管炎，以呼吸系统受累（如哮喘）最为常见。影像学表现为肺部非固定性斑片状浸润影、磨玻璃影、实变、结节、胸腔积液等，也可出现肺间充质改变。该病在成年人中常见，无明显性别差异；年龄是预后不良的影响因素之一。临床研究分析发现老年患者有更高的患病率和死亡率，本文就老年患者EGPA的临床特征进行文献复习，并综述如下。

Abstract:

Eosinophilic granulomatosis with polyangiitis (EGPA) is mainly characterized by eosinophil-rich and necrotizing granulomatous inflammation and necrotizing vasculitis, predominantly affecting small to medium vessels, often involving the respiratory tract (asthma). Its radiological manifestations are non-persistent patchy migratory pulmonary infiltrates, ground-glass opacities, consolidation, nodules, pleural effusion, and may be interstitial lung changes. EGPA is common in adults, without obvious sex predominance. Age is one of poor prognostic factors, and the aged patients tend more frequently to have complications and a higher mortality. In this article, we reviewed the literatures concerning EGPA in the elderly and summarized its clinical characteristics.