阿尔茨海默病的危险因素

Risk factors for Alzheimer’s disease

摘要:

近年来研究发现，阿尔茨海默病（AD）和其他慢性疾病一样，并非由单一因素引起，而是多种危险因素相互作用的共同结果。本文整理了可使AD发病风险增加的一些因素，包括高龄、吸烟、基因突变、APOE-ε4基因、心脑血管疾病、2型糖尿病和颅脑损伤等。探讨其在AD发生发展中的作用，为AD的防治工作奠定基础。

Abstract:

Recent researches show that Alzheimer’s disease (AD), like other common chronic diseases, develops as a result of interaction of multiple factors rather than a single cause. This article reviewed some factors that can increase the risk of AD, such as age, smoke, genetic mutations, apolipoprotein E (APOE)-ε4 gene, cardiovascular and cerebrovascular diseases, type 2 diabetes mellitus and traumatic brain injury. We aimed to discuss their roles in the development of AD, and thus provide a foundation for prevention and treatment of AD.