老年非霍奇金淋巴瘤的临床特点及预后分析

Clinical characteristics and prognosis of non-Hodgkin’s lymphoma in the elderly: based on 120 cases

摘要:

目的 探讨老年非霍奇金淋巴瘤（NHL）的临床特征和预后。方法 回顾性地分析2002年12月至2012年12月昆明医科大学第三附属医院收治的≥65岁NHL患者120例的临床资料。结果 老年NHL高发病年龄段为65～75岁；弥漫大B细胞淋巴瘤（55.0%）为最常见病理类型。患者从出现首发症状至确诊的中位时间为78d。确诊时ECOG评分0～1分者较多（62.5%）；45%的患者有伴发疾病，最常见的伴发疾病为高血压病。临床分期、全身症状、ECOG评分、国际预后指数（IPI）与总生存时间有相关性（P＜0.05）。结论 老年NHL患者合并症多，症状不典型，诊断困难，但病情发展较慢。临床分期、全身症状、ECOG评分、IPI与总生存时间有相关性。

Abstract:

Objective To investigate the clinical characteristics and prognosis of non-Hodgkin’s lymphoma(NHL) in the elderly. Methods Clinical data of 120 elderly patients with identified NHL admitted in our hospital from December 2002 to December 2012 were collected and retrospectively analyzed. Results Most of the cohort were at the age of 65 to 75 years, and had diffuse large B-cell lymphoma (55.0%) as the most common pathological type. The median time was 78d from the presentation of initial symptoms to diagnosis. When diagnosed, most patients (62.5%) had their Eastern Cooperative Oncology Group (ECOG) score from 0 to 1. Forty-five percentage of the patients suffered from comorbidities, with hypertension most common. Univariate analysis showed that the clinical stage, systemic symptoms, ECOG score, and international prognostic index (IPI) were correlated with overall survival time (P＜0.05). Conclusion Elderly NHL is characterized by multiple complications, atypical symptoms, difficulty to be diagnosed, but slower progression. Clinical stage, systemic symptoms, ECOG score and IPI are closely associated with overall survival time.