76例非霍奇金淋巴瘤患者死亡原因及影响因素分析

Cause of death and its influencing factors for non-Hodgkin’s lymphoma: analysis on 76 patients

摘要:

目的 分析非霍奇金淋巴瘤（NHL）患者的不同死亡原因及其影响因素，为临床工作提供参考。方法 回顾性分析了2004年1月～2014年12月期间，在大连医科大学附属第二医院因NHL死亡的患者，共计76例。通过对相关临床资料的统计，总结死亡原因。针对死亡原因与研究因素进行单因素分析，将单因素分析中有统计学差异的纳入logistic行多因素分析，以确定最终与死因有关的危险因素。结果 Ann Arbor分期Ⅳ期和B症状是脏器功能衰竭为死亡原因的独立危险因素。合并糖尿病及原发于淋巴结内是感染为死亡原因的独立危险因素。结论 治疗前应对NHL患者进行正确评估，重视与死亡相关的各种高危因素，进一步改善患者预后。

Abstract:

Objective To analyze the different causes of death and influencing factors for non-Hodgkin’s lymphoma (NHL) in order to provide reference for clinical practice. Methods Clinical data of 76 patients who died of NHL in our hospital from January 2004 to December 2014 were collected and retrospectively analyzed to summarize the causes of death. Univariate analysis was performed to estimate single-factor based on cause of death, and the obtained related factors further underwent multivariate logistic analysis. Results Ann Arbor Ⅳ phase and B symptoms were the independent risk factors for the organ failure induced death. The combined diabetes and primary lymph nodes tumor were the independent risk factors for the infection induced death. Conclusion NHL patients should be properly evaluated before the treatment. Attention should be paid to high-risk factors related to death in order to improve the prognosis.