Abstract:Atrial fibrillation (AF) is one of the clinically most common sustained arrhythmia, with high incidence and major hazards. In recent years, great achievements have been made in its non-pharmacologic therapeutic strategies. Among them, pulmonary vein isolation (PVI) is recommended by recent guidelines as an effective procedure to control AF, and its efficacy is higher in paroxysmal AF than in persistent and long-standing persistent AF. This article reviewed and summarized the state-of-the-art of adjunct ablation strategies for patients with persistent AF, including linear ablation, ablation of complex fractionated atrial electrograms (CFAE), ablation of ganglionated plexi, dominant frequency, rotors and other anatomical sites frequently involved in AF triggers.