复方丹参滴丸对急性冠脉综合征患者经皮冠状动脉介入治疗术前/后血液流变学的影响

Effeet of Compound Danshen Dripping pills on hemorrheology in acute coronary syndrome patients before and after percutaneous coronary intervention

摘要:

目的 观察复方丹参滴丸对急性冠脉综合征（ACS）经皮冠状动脉介入治疗（PCI）术前/后血液流变学的影响，探讨复方丹参滴丸治疗ACS的临床实用价值。方法 选择2011年1月至2013年12月在兰州大学第一医院心血管内科住院确诊ACS并行PCI治疗的患者90例，随机分为A组、B组、C组3组，每组30例。A组：于PCI术后给予常规用药，并加服复方丹参滴丸每次10粒，3次/d；B组：在PCI术及常规用药（同A组）基础上，于PCI术前加服复方丹参滴丸20粒1次，于PCI术后加服复方丹参滴丸每次10粒，3次/d；C组（对照组）：在PCI术后给予常规用药。于术前和术后3个月，检测并分析其血液流变学指标。结果 与治疗前相比，A组、B组及C组患者在全血黏度高切、低切方面，均明显降低（P＜0.05），且使用复方丹参滴丸的A组、B组在全血高切、低切方面下降得更明显，与对照组相比，差异有统计学意义（P＜0.05）。此外，A组、B组在红细胞聚集率、纤维蛋白原含量方面，与对照组相比，差异也具有统计学意义（P＜0.05）；但在血浆黏度方面，3组中经治疗后均有下降趋势，但差异无统计学意义。结论 ACS患者PCI术后在常规用药基础上加用复方丹参滴丸，可明显改善其血流动力学指标。

Abstract:

Objective To determine the effect of Compound Danshen Dripping pills on hemorrheology in acute coronary syndrome (ACS) patients before and after percutaneous coronary intervention (PCI) in order to investigate the clinical value of the pills on treatment of the disease. Methods A total of 90 patients with confirmed ACS undergoing PCI in our department from January 2011 to December 2013 were recruited in this study. Before treatment, they were randomly divided into 3 groups, that is, group A, group B, and group C, with 30 cases in each group. The patients of group A took 10 pills, 3 times per day besides conventional medication after PCI. Those of group B were given 20 pills followed by PCI surgery and took 10 pills, 3 times per day besides conventional medicine (the same as group A) after PCI. The patients of group C were treated with conventional therapy after PCI. Hemorrheological parameters were measured before and in 3 months after surgery. Results Compared with the parameters before treatment, whole blood viscosity at low and high shear rates were significantly lower in the 3 groups (P＜0.05), more significant changes were found in group A and B when compared with group C (P＜0.05). In addition, group A and group B had significant differences in erythrocyte aggregation rate and fibrinogen level compared with group C (P＜0.05). However, plasma viscosity was decreased in the 3 groups after treatment, but the difference was not statistically significant. Conclusion Compound Danshen Dripping pills combined with conventional medication significantly improve the hemodynamic parameters in ACS patients after PCI.