apelin与动脉粥样硬化的关系

Relationship between apelin and atherosclerosis

摘要:

apelin是新近发现的脂肪因子，可通过多种途径参与动脉粥样硬化的发展。其可能机制是参与胰岛素抵抗和脂代谢异常，进而影响动脉粥样硬化的发展；直接影响血管内皮细胞的炎性反应状态，促进单核细胞向血管内皮细胞黏附、迁移；促进细胞内胆固醇流出，减少泡沫细胞的形成；增加斑块稳定性，抑制斑块破裂及血栓形成。深入研究apelin与动脉粥样硬化的关系将为动脉粥样硬化的防治提供新靶点。

Abstract:

Apelin is a newly discovered adipokine, and participates in the development of atherosclerosis in various ways. The possible mechanisms included that it is involved in insulin resistance and abnormal lipid metabolism, and then influences the development of atherosclerosis; it directly affects the inflammatory state of vascular endothelial cells and promotes monocytes to migrate and adhere to endothelial cells; it promotes cellular cholesterol efflux and reduces the formation of foam cells; it enhances plaque stability, and prevents plaque rupture and thrombosis formation. Further study on the relationship of apelin with atheroselerosis thoroughly will provide a new target for prevention and treatment of atherosclerosis.