老年隐蔽性高血压患者同型半胱氨酸及部分炎症因子水平的效率

Plasma levels of homocysteine and some inflammatory factors in elderly masked hypertensive patients

摘要:

目的 分析血浆同型半胱氨酸（Hcy）、超敏C?反应蛋白（hs-CRP)、白介素?6（IL-6）在老年隐蔽性高血压患者中的水平。方法 选取2012年1月至2013年10月石河子大学医学院第一附属医院老年病科及新疆维吾尔自治区人民医院米东分院内科住院的＞65岁的老年患者，动态血压明确诊断为老年隐蔽性高血压患者60例为隐蔽性高血压组，另选取同期住院健康体检60例非隐蔽性高血压患者为对照组，两组性别、年龄匹配，同期测定血浆Hcy、hs-CRP、IL-6水平，比较两组间差异。结果 隐蔽性高血压组血Hcy水平为（17.64±7.94）mmol/L，对照组为（11.03±5.35）mmol/L，两组间差异有统计学意义（P＜0.01）。隐蔽性高血压组hs-CRP、IL-6分别水平为（0.61±0.15）mg/L、（0.20±0.05）mg/L，对照组为（0.50±0.14）mg/L、（0.16±0.04）mg/L，两组间比较差异均有统计学意义（P＜0.05）。结论 老年隐蔽性高血压患者Hcy、hs-CRP、IL-6水平升高，但他们是否参与老年隐蔽性高血压的发病有待进一步研究。

Abstract:

Objective To determine the plasma levels of homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in the elderly patients with masked hypertension. Methods A total of 60 elderly in-patients (over 65 years old) with masked hypertension confirmed by ambulatory blood pressure monitoring admitted in our department and Midong District Branch from January 2012 to October 2013 were recruited in this study as masked hypertension group. Another 60 elderly individuals without masked hypertension who took physical examination in our hospital during same period served as control group. The gender and age well matched between two groups. Plasma levels of Hcy, hs-CRP and IL-6 were detected in all the patients, and the results were compared between the 2 groups. Results The plasma level of Hcy was significantly higher in the masked hypertension group than in the control group [(17.64±7.94) vs (11.03±5.35)mmol/L, P＜0.01]. The masked hypertension group also had obviously higher plasma hs-CRP [(0.61±0.15)mg/L and IL-6 levels (0.20±0.05)mg/L] than the control group [(0.50±0.14)mg/L and (0.16±0.04)mg/L respectively, P＜0.05]. Conclusion Plasma levels of Hcy, hs-CRP and IL-6 are higher in elderly masked hypertensive patients than in those without masked hypertension. Whether Hcy, hs-CRP and IL-6 be involved in the pathogenesis of the elderly masked hypertension needs further study.