Abstract:Objective To investigate the effect of aerobic exercise plus resistance exercise training on myocardial microcirculation and infarct size in the patients with acute myocardial infarction (AMI) so as to provide wider range of treatment options for the disease. Methods A total of 86 patients with initial AMI admitted in our department from January 2013 to December 2014 were enrolled in this study. They were randomly divided into treatment group (n=43) and control group (n=43). The patients of both groups were treated with drug therapy, and those from the treatment group underwent a 12-week aerobic exercise plus resistance training. Myocardial microcirculation and infarct size, including maximal oxygen consumption (VO2max), maximal oxygen consumption/kg (VO2max/kg), maximal oxygen consumption /heart rate (VO2max/HR), maximal heart rate (HRmax), maximal voluntary ventilation (VEmax) and the results of myocardial contrast echocardiography (MCE) were measured before and at the end of treatment and compared between the 2 groups. Results There as no significant demographic difference between the 2 groups before treatment (P>0.05). Aerobic exercise plus resistance training significantly improved VO2max, VO2max/kg, VO2max/HR, HRmax and VEmax, compared with those of control group (P<0.05). The A, κ and A·κ levels had no significant demographic difference between the 2 groups before treatment (P>0.05), but the levels were significantly higher in the treatment group than in control group in 12 weeks after treatment (P<0.05). Conclusion The aerobic exercise plus resistance training is effective intervention to improve microcirculation and infarct size in patients with AMI. This intervention may provide a new option and wider measures for further treatment of patients with AMI.