Abstract:Basic and clinical researches have shown that diabetes mellitus is commonly coexisting with depression, and the symptoms of the comorbidity are quite complicated, thus increasing the difficulty in the treatment and nursing for both of them in clinical practice. These two diseases interact with each other, and one is risk factor for another at the same time. What’s more, the mechanism underlying their relationship remains unclear. The paper reviewed the possible mechanism of the comorbidity of diabetes and depression, their mutual influence and research progress in their treatment, and aimed to highlight the relevance between them, so as to provide theoretical basis for clinical individualized diagnosis and treatment.