糖化蛋白及其在高海拔地区的相关研究

Glycosylated proteins in diabetes and at high altitude

摘要:

研究表明，糖尿病患者体内多种蛋白质可与血糖发生缓慢、稳定、不可逆的生化效应形成可测定的相应的糖基化终末产物，如糖化血红蛋白（HbA1c）及糖化白蛋白（GA）。HbA1c、GA水平与血糖及糖尿病并发症密切相关，且其检测结果受血红蛋白（Hb）及白蛋白等因素的影响。高原地区高海拔、低氧、寒冷等独特的地理、气候条件使得人体内多器官、系统的病理及生理有别于平原地区，这些变化使糖尿病患者的诊治较平原地区更为复杂、特殊。本文就HbA1c、GA及其在高原地区的相关研究做一综述。

Abstract:

Evidence shows that various proteins in diabetic patients are glycosylated in a slow, stable, and irreversible biochemical reaction, and then form some determinable glycosylation end products, such as glycosylated hemoglobin A (HbA1c) and glycosylated albumin (GA). Serum levels of HbA1c and GA are closely associated with blood glucose and diabetes complications, and their test results are affected by some factors, such as hemoglobin (Hb) and albumin. Hypoxia, cold and other unique geographical and climatic conditions at the high altitude make the multi-organic and multi-systematic pathological and physiological status of human body different from those living at the plains, and these differences make the diagnosis and treatment of diabetes patients who live at the high altitude more complicated and distinctive than people at the plain area. This review mainly introduced HbA1c, GA and some related investigations at the high altitude.