1,5-脱水葡萄糖醇的临床应用及研究进展

Clinical application of 1,5-anhydroglucitol and the research progress

摘要:

1,5-脱水葡萄糖醇（1,5-AG）是体内的一种无生理活性的多元醇，其在肾小管内的重吸收过程可被葡萄糖竞争性抑制。当血糖水平超过肾糖阈时，血清1,5-AG水平将快速下降，利用此特性，1,5-AG可用以反映短时间内血糖波动情况。本篇综述整理了1,5-AG的特点，目前在临床上的研究进展，以及1,5-AG在临床应用中的优势和局限性。

Abstract:

1,5-Anhydroglucitol (1,5-AG) is a metabolically inert polyol that competes with glucose for reabsorption in the kidneys. The stable level of 1,5-AG is rapidly depleted as blood glucose levels exceed the renal threshold for glucosuria. Thus, 1,5-AG can be used as a validated marker of short-term glycemic control. This article reviewed the features and research progress of 1,5-AG and assessed its advantages as well as limitations as a glycemic marker in clinical practice.