老年射血分数保留心力衰竭患者危险因素分析

Risk factors for heart failure with preserved ejection fraction in the elderly

摘要:

目的 回顾性分析老年射血分数保留心力衰竭（HFpEF）患者的临床及超声心动图参数，与无症状舒张功能不全的非心衰患者比较，明确HFpEF的危险因素。方法 入选2011年12月至2012年12月在首都医科大学附属北京友谊医院医疗保健中心心血管内科就诊的234例患者（年龄≥60岁），分为无症状舒张功能不全组（ADD组）104例和射血分数保留心力衰竭组（HFpEF组）130例。通过回归分析明确HFpEF的独立危险因素。结果 与ADD组相比，HFpEF患者的平均年龄较大，估测的肾小球滤过率较低。logistic回归分析表明冠心病、高血压和慢性阻塞性肺疾病（COPD）是HFpEF的独立危险因素（P＝0.001，0.031，0.003）。结论 老年患者中，冠心病、高血压和COPD与HFpEF相关。

Abstract:

Objective To determine the risk factors for heart failure with preserved ejection fraction (HFpEF) in the elderly by retrospectively analyzing their clinical features and echocardiographic parameters of HFpEF patients and comparing with those of non-heart failure patients with asymptomatic diastolic dysfunction. Methods A total of 234 consecutive patients (≥60 years old) admitted in our department from December 2011 to December 2012 were enrolled in this study. They were divided into asymptomatic left ventricular diastolic dysfunction group (ADD group, n＝104) and HFpEF group (n＝130). Risk factors of HFpEF were analyzed by logistic regression. Results Compared with ADD group, the patients in HFpEF group were older and had a lower estimated glomerular filtration rate (eGFR) (P＜0.05). Logistic regression analysis indicated that coronary artery disease(CAD), hypertension, and chronic obstructive pulmonary disease (COPD) were independent risk factors of HFpEF (P＝0.001, 0.031, 0.003, respectively). Conclusion CAD, hypertension and COPD are associated with HFpEF in this cohort.