非对称性二甲基精氨酸与认知障碍的关系

Asymmetric dimethylarginine and cognitive impairment

摘要:

非对称性二甲基精氨酸（ADMA）是内源性一氧化氮合酶（NOS）抑制剂，可以抑制血管活性物质一氧化氮（NO）生成，导致内皮功能障碍。研究表明，ADMA可能通过参与脑血量减低、动脉粥样硬化、脑白质稀疏和氧化应激，导致记忆障碍和痴呆的发生和发展。干扰ADMA的合成或代谢可能为防治认知障碍开辟一条新途径。

Abstract:

Asymmetric dimethylarginine (ADMA) is an inhibitor of endogenous nitric oxide synthase (NOS), which inhibits the formation of vasoactive substance, nitric oxide (NO), and further results in endothelial dysfunction. Some studies have shown that ADMA may cause the occurrence and development of memory impairment and dementia through being involved in cerebral blood flow reduction, atherosclerosis, leukoaraiosis and oxidative stress. So, interference of synthesis or metabolism of ADMA may bring forward a new means to prevent and treat cognitive impairment.