肠屏障功能检测方法的研究现状及展望

Examination for intestinal mucosal barrier function: current status and prospects

摘要:

肠屏障功能障碍是导致全身炎症反应综合征、多器官功能不全综合征，甚至多器官功能衰竭的一个重要因素。早期判断患者有无肠黏膜损伤并进行有效干预意义重大，因此加大对肠屏障功能检测方法的研究力度具有重要意义。本文就肠脂肪酸结合蛋白、瓜氨酸、D-乳酸等常用的肠屏障功能检测指标及方法予以综述。

Abstract:

Intestinal mucosal barrier dysfunction is an important factor resulting in systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and even multiple organ failure. So it is of great significance to assess intestinal mucosal lesion and make early effective intervention. Therefore, more efforts should be taken to study how to evaluate intestinal mucosal barrier function. In this paper, we reviewed some common indices indicating intestinal mucosal barrier function (fatty acid binding protein, citrulline and D-lactic acid), and the involved methods in clinical practice.