Abstract:Large conductance Ca2+-activated K+ channels (BKCa channel) are found to be abundantly expressed in the membrane of coronary vascular smooth muscle cells, and play an important role in the maintenance of cellular physiological functions. Evidence shows that cell membrane depolarization and/or increase in intra-cellular Ca2+ activates BKCa channels, then the opening of the channels enables K+ efflux, thus finally, membrane hyperpolarization and vasodilation take place. However, the functions of BKCa channels are altered under some pathophysiological conditions, such as hypertension, diabetes mellitus, hypoxia, heart failure, aging and so on. This alteration exerts dramatic impacts on vascular functions. The paper mainly reviewed the recent research progress in BKCa channel in cardiovascular diseases.