自体骨髓间充质干细胞移植治疗心肌梗死的进展

Autologous bone marrow mesenchymal stem cells transplantation in treatment of myocardial infarction: recent advances

摘要:

心肌梗死可引起心肌细胞的丢失，进而引起心脏功能的下降，是心力衰竭最主要的病因。骨髓间充质干细胞（BM-MSCs）是一类具有横向分化为各系统器官和组织能力的干细胞，能补充丢失的心肌细胞并通过旁分泌等机制增强心功能，为心肌梗死提供一种全新的治疗方法，极具发展潜力。本文对BM-MSCs的分离培养、诱导因素、移植以及临床研究等方面进行了综述。

Abstract:

Myocardial infarction is the main cause of heart failure, causing the loss of myocardial cells, and then declining the cardiac function. Bone marrow derived mesenchymal stem cells (BM-MSCs) are stem cells with capacity for self-renewal and potential to differentiate into a broad tissue distribution. BM-MSCs after transplantation can survive in the myocardium and then improve cardiac function through paracrine and other mechanisms. The cell transplantation provides a new approach for treatment of myocardial infarction and has great application potential. In this paper, we reviewed the current understanding of BM-MSCs isolation, induction, transplantation and recent clinical research on the therapy for cardiac diseases.