肝再生磷酸酶-3与恶性肿瘤关系的研究进展

Relatioship between phosphatase of regenerating liver-3 and malignant tumors: research progress

摘要:

肝再生磷酸酶-3（PRL-3）属于蛋白酪氨酸磷酸酶家族，它发挥作用的方式是通过调节酪氨酸残基的磷酸化状态实现对蛋白质活性的调控。已有的研究表明，PRL-3与人多种肿瘤的发生、发展、转移及预后密切相关，可能参与调节肿瘤细胞的骨架重建、细胞黏附性和上皮间充质化的过程，这可能成为治疗多种类型肿瘤的药物靶点。本文对PRL-3与肿瘤关系的研究现状和进展做一综述。

Abstract:

Phosphatase of regenerating liver-3 (PRL-3) belongs to a protein tyrosine phosphatase family, and regulates the protein activity by modifying the phosphorylation of tyrosine residues. Previous studies reported that PRL-3 was closely involved in the occurrence, development, metastasis and prognosis of many kinds of malignant tumors. It probably participats in the reconstruction of the cytoskeleton, the regulation of cell adhesion, and the process of epithelial-mesenchymal transition. PRL-3 might be a promising target for developing drugs in cancer treatment. In this paper, we reviewed the research progress in the relationship between PRL-3 and cancer.