补肺活血胶囊对慢性阻塞性肺疾病患者肺功能的影响

Efficiency of Bufeihuoxue capsule on pulmonary function in elderly with chronic obstructive pulmonary disease

摘要:

目的 探讨补肺活血胶囊对慢性阻塞性肺疾病（COPD）患者肺功能的影响，并探索其可能的机制。方法 回顾性地分析2010年3月至2012年3月在第三军医大学西南医院住院接受治疗的170例COPD患者的临床资料。其中，常规治疗组（n＝50）患者给予常规的COPD治疗，联合治疗组（n＝120）在常规治疗的基础上给予补肺活血胶囊口服。检测两组患者的肺功能指标，包括第1秒用力呼气容积和第1秒呼气量占用力肺活量的百分比（FEV1和FEV1/FVC），统计急性发作次数，采用酶联免疫法（ELISA法）分别测定C-反应蛋白（CRP）、纤维蛋白原（Fib）和D-二聚体（D-D）的含量。结果 与常规治疗组比较，联合治疗组患者的肺功能得到不同程度的改善，尤其是FEV1/FVC较常规治疗组明显升高，急性发作次数明显减少，CRP，Fib和D-D均有不同程度的降低，差异均有统计学意义（P＜0.05）。结论 补肺活血胶囊可以改善COPD患者的肺功能，其机制可能与改善患者的炎症反应及肺部微血流状态等有关。

Abstract:

Objective To investigate the effect of Bufeihuoxue (BH) capsule, a Chinese Traditional Medicine, on pulmonary function in patients with chronic obstructive pulmonary disease (COPD), and to explore its possible mechanism. Methods A total of 170 COPD patients admitted in our hospital from March 2010 to March 2012 were subjected in this study. They were randomly divided into 2 groups, one group of patients were given regular COPD treatment (routine treatment group, n＝50), and the others were given BH capsule combined with conventional therapy (combined treatment group, n＝120). The pulmonary function, including forced expiratory volume in one second (FEV1) and forced vital capacity rate of one second (FEV1/FVC) was tested in 2 groups of patients. Acute outbreak of COPD was recorded. Serum levels of C-reactive protein (CRP), fibrinogen (Fib) and D-dimer (D-D) were determined by enzyme-linked immunosorbent assay (ELISA) before and after treatment. Results Compared with routine treatment group, combined treatment group had significantly improved lung function, especially shown as elevated FEV1/FVC, and decreased times of acute outbreak, and reduced serum contents of CRP, Fib and D-D (P＜0.05). Conclusion BH capsule can improve lung function in patients with COPD, and its mechanism may be related to the improvement of patients’ inflammatory reaction and pulmonary microvascular blood flow.