葡萄糖耐量受损需要干预吗？

Intervention for impaired glucose tolerance, necessary or not?

摘要:

葡萄糖耐量受损（IGT）是最主要的糖调节异常，在糖尿病前期人群中占有较大的比例。IGT人群是2型糖尿病最重要和最需要重点关注的高危人群，如果不进行积极有效的干预，每年有10%～15%的IGT患者会进展为2型糖尿病。如进行积极干预，则可以延缓这一进程，甚至实现逆转。IGT人群也是心血管疾病的高危人群，来自临床的数据表明，IGT人群罹患各种心血管疾病的风险要显著高于糖代谢正常的正常人群。因此，对于IGT人群，必须给予积极和有效的干预，从而达到预防糖尿病和减低心血管事件风险的目的。干预IGT，首选生活方式干预，当单独采取生活方式干预无法达到预期目标时，可采取药物干预措施。

Abstract:

Impaired glucose tolerance (IGT) is the most common form of impaired glucose regulation, and accounts for major proportion of people with prediabetes. People with IGT are at high risk for type 2 diabetes mellitus, and 10% to 15% of them will progress into diabetes every year if not receiving effective intervention. But if they are treated properly, this process can be delayed or even reversed to normal healthy state. People with IGT are also vulnerable for cardiovascular diseases. Clinical evidence shows that they are prone to suffer from cardiovacular events than those with normal glucose tolerance. So for the people with IGT, active and effective intervention must be carried out to prevent diabetes and cardiovascular events. Life style intervention should be of the first choice to intervene IGT, and drugs can be added if life style intervention fails to meet the target.