老年患者术后认知障碍炎症机制的研究进展

Inflammatory mechanism of postoperative cognitive dysfunction in the elderly: a research update

摘要:

术后认知障碍（POCD）是老年患者严重的术后并发症。POCD大大增加了老年患者术后致残和致死风险，严重降低患者的生活质量。但目前POCD具体发病机制仍不清楚，尚缺乏有效的治疗方法。近些年的研究结果提示术后炎症反应是POCD发病的主要机制，本文将从临床研究和基础研究两方面对POCD炎症机制的研究进展做一综述，并对有助于改善POCD的抗炎药物做一介绍。

Abstract:

Postoperative cognitive dysfunction (POCD), one of severe postoperative complications in elderly patients, greatly increases the risk of postoperative morbidity and mortality, and severely reduces the quality of life at the same time in these patients. However, since the pathogenesis of POCD remains unclear, effective treatment has not been defined yet. Recent evidences suggest that postoperative inflammation be the main mechanism for POCD. This article reviewed the inflammatory mechanisms of POCD based on basic and clinical researches, and also introduced some anti-inflammatory drugs which are beneficial to POCD treatment.