高尿酸血症与糖尿病及其血管并发症

Relationship of hyperuricemia with diabetes and its vascular complications

摘要:

高尿酸血症与糖尿病密切相关，同时参与糖尿病性心血管疾病以及糖尿病肾病的发生和发展。高尿酸血症主要是通过导致胰岛素抵抗参与糖尿病的发生，同时通过引起内皮功能损伤、诱发炎症反应等参与糖尿病性心血管疾病以及糖尿病性肾病的发生。本文主要探讨高尿酸血症与糖尿病及其血管并发症的发病情况及可能的发病机制。

Abstract:

Hyperuricemia has a close correlation with diabetes, and also participates in the incidence and development of diabetic cardiovascular diseases and nephropathy. Hyperuricemia is involved in the pathogenesis of diabetes mainly through insulin resistance, and also contributes to the occurrence of diabetic cardiovascular diseases and nephropathy by endothelial dysfunction and inflammatory cascade reaction. This review mainly elucidates the prevalence and possible mechanism of diabetes and its vascular complications caused by hyperuricemia.