Abstract:Objective To investigate the correlation of albuminuria with ambulatory blood pressure pattern in the very old patients with hypertension. Methods Seventy very old hypertensive subjects admitted to Beijing Friendship Hospital from June 2012 to June 2013 were enrolled in this study. Their clinical data, urinary albumin excretion rate, ambulatory 24-hour blood pressure monitoring results were collected. The patients were divided into albuminuria group (n=32) and non-albuminuria group(n=38) according to the results of urinary test. Day systolic blood pressure(dSBP) and day diastolic blood pressure(dDBP), night systo1ic blood pressure(nSBP) and night diastolic blood pressure(nDBP) were compared between the 2 groups. Night blood pressure descend and blood pressure pattern were also observed in the 2 groups. Results There was no significant difference in the age, gender, diabetes incidence, high sensitivity C reactive protein, ejection fraction between the 2 groups(P>0.05). Estimated glomerular filtration rate(eGFR) was significantly lower in albuminuria group than in the non-albuminuria group(P<0.05). Ambulatory 24-hour blood pressure monitoring indicated that the dSBP and dDBP were normal in the 2 groups, without significant difference(P>0.05). The albuminuria group had significantly higher nSBP than the non-albuminuria group (P<0.01). There was no significant difference in the non-dipper blood pressure between the 2 groups, but the albuminuria group had higher rate of reversed dipper blood pressure(P<0.01). Conclusion Increased nSBP, that is, the reversed dipper blood pressure pattern, is closely related to albuminuria and decreased eGFR in the very old patients with hypertension.