舍曲林对老年良性前列腺增生伴抑郁患者的疗效

Efficiency of sertraline in elderly benign prostatic hyperplasia patients with depression

摘要:

目的 考察舍曲林对老年良性前列腺增生（BPH）伴抑郁患者的疗效。方法 将2011年1月至2012年5月由解放军总医院第一附属医院干部病房二科收治的118例老年BPH伴抑郁的患者随机分为治疗组（60例）和对照组（58例）。对照组采取常规前列腺增生治疗，治疗组在常规前列腺增生治疗基础上，同时给予抗抑郁药物舍曲林治疗12周。在治疗前及治疗后2，4，8，12周，使用汉密尔顿抑郁量表（HAMD-17）和汉密尔顿焦虑量表（HAMA）评定抗抑郁焦虑疗效，使用治疗不良反应量表（TESS）评定药物不良反应，治疗前后使用生活质量综合评定问卷（GQOLI-74）评定生活质量的变化。分别进行两组治疗前后对比分析，评价舍曲林对患者抑郁焦虑症状的疗效及对生活质量的影响。结果 经12周治疗后, 治疗组患者的抑郁、焦虑症状显著改善（P＜0.01）。生活质量的心理健康和社会功能方面明显高于治疗前，并且高于对照组，差异有统计学意义（P＜0.05，P＜0.01）。结论 舍曲林对BPH伴抑郁患者的疗效显著，有利于改善患者的生活质量。

Abstract:

Objective To determine the curative effects of sertraline in the treatment of the elderly benign prostatic hyperplasia(BPH) patients with depression and its influence on patients’ quality of life. Methods Totally 118 elderly BPH patients with depression admitted to our department from January 2011 to May 2012 were enrolled in this study, and randomly assigned into treatment group(n＝60) and control group(n＝58). All patients were treated with conventional drugs for BPH, while those from treatment group were additionally treated with sertraline for 12 weeks. All patients were evaluated with Hamilton Depression Rating Scale(HAMD-17), and Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of 2, 4, 8, and 12 weeks after treatment, and at the same time with Generic Quality of Life Inventory(GQOLI-74) before treatment and at the ends of 12 weeks treatment. Results After 12 weeks treatment, great improvement was achieved in treatment group in their depressive and anxious symptoms(P＜0.01). And they also had higherscores in physical health, mental health and social function in quality of life than those before treatment and those in the control gourp(P＜0.05, P＜0.01). Conclusion Sertraline has significant effectiveness in the treatment of the elderly BPH patients with depression, and also significantly improves their quality of life.