血管弹性随年龄进行性减低310例的自身对照分析

Self-control analysis on vasoactivity with aging: report of 310 cases

摘要:

目的 纵向研究同一人群臂踝脉搏波速度（baPWV），探讨血管弹性随年龄进行性减低的情况。方法 以2008年沈阳地区人群队列为基础，按年龄每10岁分为一组：44岁及以下、45～54岁、55～64岁、65～74岁、75岁及以上共5组。分别评估血脂、血糖等生化指标，动脉硬化检测仪检测的四肢血压（包括收缩压、舒张压、脉压差），baPWV等；3年后再次进行动脉硬化检测。对其中310例完成两次动脉硬化检测的人群，进行自身对比分析。结果 两次测定的baPWV及baPWV变化值在不同年龄组间存在显著差异（均为P＜0.01），baPWV和baPWV变化值与年龄呈正相关（均为P＜0.01）；经自身对照分析，baPWV在两次检查中存在显著差异（P＜0.01），baPWV的变化值随年龄增加而增大（P＜0.01）。结论 baPWV的变化与年龄增加有关系。增龄引起血管弹性进行性减低且随年龄增加而加剧。

Abstract:

Objective To explore the brachial-ankle pulse wave velocity (baPWV) in the same cohort longitudinally in order to investigate the decreasing rate of vasoactivity with aging. Methods Based on the people cohort in 2008 in Shenyang, the people were divided into ≤44-year-old, 45- to 54-year-old, 55- to 64-year-old, 65- to 74-year-old and ≥75-year-old groups according their age in the year of 2008. Biochemical methods were used to detect their blood lipid and glucose indices. A full-automatic arteriosclerosis detector was employed to measure blood pressures of bilateral brachial artery and anterior tibial artery (including systolic blood pressure, mean arterial pressure, diastolic blood pressure, and pulse pressure). Ankle-arm index (ABI and baPWV) were also calculated. The same tests were conducted again in 3 years later. There were totally 310 patients who fulfilled all detection. Self-control analysis on the vasoactivity was carried out. Results There were significant differences in baPWV and baPWV alteration among different age groups (P＜0.01 for all). There was positive correlation of baPWV and baPWV alteration with age (P＜0.01 for all). Self-control analysis showed baPWV was significantly different in the 2 times of examination (P＜0.01), and baPWV alteration was more significant with aging (P＜0.01). Conclusion There is association between getting older and change of baPWV. Progressively reduced vasoactivity caused by getting older becomes aggravated with aging.