NADPH氧化酶p22phox亚基基因多态性与高血压左心室肥厚的相关性

Correlation of p22phox gene polymorphism of NADPH oxidase with left ventricular hypertrophy in hypertensive patients

摘要:

目的 探讨中国汉族人群中NADPH氧化酶p22phox亚基C242T基因多态性与高血压左心室肥厚（LVH）的相关性。方法 连续收入初诊汉族原发性高血压患者286例，超声心动图评估并计算患者左心室质量指数，将患者分为单纯高血压和高血压合并LVH，并记录体质量指数、血压、血糖和血脂等。同时，采用限制性片段长度多态性鉴定p22phox亚基C242T基因型。结果 全部患者中均未检出TT基因型，而高血压合并LVH的患者中CT基因型（P＝0.002）和T等位基因出现的频率（P＝0.005）均显著高于单纯高血压患者。Logistic回归分析显示p22phox亚基C242T多态性与性别、收缩压同为高血压合并LVH的独立影响因素，存在Ｔ突变的高血压患者合并LVH的风险降低63%（P＝0.007）。结论 CYBA C242T多态性与中国汉族高血压患者LVH相关，T等位基因可能是LVH的保护因素。

Abstract:

Objective To investigate the correlation of the C242T polymorphism of NADPH oxidase p22-phox gene with left ventricular hypertrophy (LVH) in Chinese Han hypertensive subjects. Methods A total of 286 consecutive patients of Han nationality with newly diagnosed essential hypertension admitted in our hospital from January 2008 to December 2011 were enrolled in this study. They were all evaluated with echocardiography for left ventricular mass index, and were divided into hypertension with or without LVH. Body mass index (BMI), blood pressure, fasting blood glucose, triglycerides and total cholesterol were documented. P22-phox C242T polymorphism was analyzed by restriction fragment length polymorphism (RFPL). Results The frequencies of CT genotype and T allele were significantly higher in the patients with LVH patients than those without LVH (P＝0.002, P＝0.005), but no any case of TT genotype was found. Logistic analysis showed that the C242T polymorphism in NADPH oxidase p22phox, as well as female sex and systolic blood pressure were independent risk factors for LVH. Compared to patients with CC genotype, the risk of LVH was decreased by 63% in those with CT genotype (P＝0.007). Conclusion The C242T polymorphism in NADPH oxidase p22phox is correlated with LVH in Chinese hypertensive patients. The T allele might be protective factor for LVH.