Abstract:Objective To determine the therapeutic effect of polyene phosphatidylcholine (PPC) combined with valproic acid magnesium(VPA-Mg) on cognitive function in patients with epilepsy. Methods A total of 42 outpatients with identified epilepsy in Xijing Hospital during December 2011 to September 2012 were randomly divided into 2 matched groups, that is, VPA-Mg+PPC group (n=20) and VPA-Mg group (n=22). Their clinical data before, and in 4, 12 and 24 weeks after treatment were observed and analyzed. The Beijing version of Montreal cognitive assessment and the Alzheimer¢s disease assessment scale-cognitive were used to evaluate their cognitive function. Results There was no significant difference in the course of disease, seizure types, monthly average seizure frequency and levels of education attainment between the two groups. Monthly average seizure frequency was significantly decreased in VPA-Mg+PPC group 24 weeks after treatment (1.2±1.1 vs 0.4±0.6, P<0.05). The same was in VPA-Mg group (1.5±1.4 vs 0.6±0.6, P<0.05). But no significant difference was found between the two groups (P>0.05). Cognitive evaluation was more obviously improved in VPA-Mg+PPC group than in VPA-Mg group (P<0.05). No severe complication was found during treatment, but there were mild adverse reactions and abnormal laboratory results in VPA-Mg group. There were 1 case of chest tightness, 1 case of alopecia, 1 case of abdominal pain, and 2 cases of mildly increased glutamic-pyruvic transaminase. There was no such adverse reaction in VPA-Mg+PPC group, and liver functions were restored to normal in some cases. Conclusion Combined therapy of VPA-Mg and PPC not only controls the seizures in patient with epilepsy, resists adverse reactions in the liver caused by VPA-Mg, but also improves their cognitive impairment.