脓毒症免疫细胞凋亡研究进展

Apoptosis of immune cells in sepsis: an update review

摘要:

尽管有关脓毒症基础和临床研究均取得一定进展，脓毒症发病率和死亡率依然居高不下，临床脓毒症的诊治面临极大的困难，成为威胁人类健康的主要原因之一。近十年来，大量有关脓毒症病理生理过程中细胞凋亡的研究使人们逐渐认识到，树突状细胞、巨噬细胞、T淋巴细胞等免疫效应细胞过度凋亡是导致脓毒症免疫功能紊乱的关键环节，抑制上述细胞凋亡能够显著改善机体免疫状态，提高脓毒症动物的生存率。因此，明确脓毒症状态下，免疫细胞发生凋亡的诱导因素和信号传导途径就显得尤为重要，本文就免疫细胞凋亡在脓毒症发病机制中的地位及新的干预手段进行综述。

Abstract:

Nowadays, sepsis is associated with high morbidity and mortality, despite certain achievement has been made in its basic and clinical research. Because of its difficulty in the diagnosis and treatment, it is one of the most common health-threatening diseases. Over the past decade, many studies on septic animals and patients have highlighted immune cell apoptosis in the pathophysiological process of aggravating sepsis. Excessive apoptosis of dendritic cells, macrophages, T lymphocytes and other immune effector cells is the key aspect of immune dysfunction. In addition, accumulated evidence demonstrates that prevention of cell apoptosis can significantly improve the immune status and the survival rate in clinically relevant animal models of sepsis. Therefore, it is quite important to confirm the inducing factors and signaling pathways in the immune cell apoptosis. In this paper, we summarized the role of immune cell apoptosis in pathophysiology of sepsis, and the novel therapeutic strategies based on prevention of apoptosis.