纳米炭在乳腺癌腋窝淋巴结清扫中的临床应用

Application of carbon nanoparticles suspension injection to axillary lymph node dissection in breast cancer

摘要:

目的 探讨纳米炭混悬注射液在乳腺癌淋巴结清扫术中的价值。方法 64例乳腺癌患者随机分为两组，一组注射纳米炭示踪，一组为空白对照。两组行乳腺癌改良根治术，统计术后淋巴结获检情况。结果 术中可见纳米炭组淋巴结有不同程度的染色，32例患者平均检出淋巴结（27.4±5.7）枚，对照组平均检出淋巴结（21.1±4.2）枚，差异有统计学意义（P＜0.001）。在纳米炭组中，淋巴结黑染率84.6%（741/876），黑染组淋巴结转移率为33.6%（249/741），未黑染组淋巴结转移率为39.3%（53/135）。两组差异无统计学意义（P＝0.257）。结论 术前注射纳米炭混悬液对乳腺癌淋巴结清扫术有指导意义。

Abstract:

Objective To evaluate the application of carbon nanoparticles suspension injection to the axillary lymph node dissection in breast cancer. Methods Sixty-four patients with breast cancer were divided into two groups, one group was given carbon nanoparticles suspension injection before operation, the other was blank control group. All patients received modified radical mastectomy. Lymph nodes were collected and recorded for pathologic examination. Results In the carbon nanoparticles group, lymph nodes and lymph tracts staining were found in the surgery, with an average lymph node detection number of 27.4±5.7 per patient. In the control group, the average number was 21.1±4.2. The difference between the two groups was statistically significant (P＜0.001). In the carbon nanoparticles group, the black staining rate of lymph nodes under naked eye was 84.6% (741/876). The rate of metastasis in black lymph nodes was 33.6% (249/741), in unmapping lymph nodes was 39.3% (53/135). There was no statistically difference between the two groups (P＝0.257). Conclusion Carbon nanoparticles suspension injection is helpful for axillary lymph node dissection and evaluation of metastatic status of the axillary lymph nodes in breast cancer.