脉搏波传导速度与心血管危险因素及Framingham积分的相关性

Correlation of brachial ankle pulse wave velocity with cardiovascular risks and Framingham score

摘要:

目的 研究臂踝脉搏波传导速度（baPWV）和心血管危险因素、Framingham积分之间的关系。评估baPWV对心血管事件的预测价值。方法 将144例研究对象分为冠心病组（48例）与非冠心病组（96例），非冠心病组根据是否存在心血管危险因素分为正常对照组（46例）、危险因素组（50例）。应用动脉硬化检测仪检测baPWV。结果 三组之间baPWV差异有统计学意义（P＜0.01）。校正年龄后，三组baPWV差异仍具有统计学意义（P＜0.05）。baPWV与多重传统危险因素正相关。其中，年龄、收缩压为baPWV的独立预测因子，二者影响相当。baPWV与Framingham积分正相关（P＜0.01）。应用受试者工作特征曲线分别评价baPWV对冠心病诊断、冠心病高危人群筛查的预测价值，曲线下面积分别为0.768和0.944。结论 baPWV与心血管危险因素具有良好的相关性，对冠心病的诊断具有中等预测价值，对冠心病高危人群筛查具有较高预测价值。

Abstract:

Objective To study the relationship of brachial ankle pulse wave velocity(baPWV) with cardiovascular risks and Framingham score, and to estimate the predictive value of baPWV in cardiovascular events. Methods Totally 144 subjects were enrolled and divided into coronary heart disease group (48 cases), non-CHD with cardiovascular risk group (50 cases) and non-CHD without cardiovascular risk group (46 cases). baPWV was detected by artery stiffness testing measurement equipment. Results There was significant difference in baPWV among three groups (P＜0.01). After adjusting age, the difference in baPWV between the three groups was still significant(P＜0.05). baPWV was positively correlated with conventional cardiovascular risks. Moreover, age and systolic blood pressure were independent indicators of baPWV. baPWV was also positively correlated with Framingham risk score. The predictive value of baPWV was reviewed by using receiver operating characteristic (ROC) curve. Area under ROC curve was 0.768 in CHD group and 0.944 in CHD high-risk group. Conclusion There is good relationship between baPWV and cardiovascular risk factors, and the value of baPWV is moderate in predicting CHD and high in screening population with high risk stratification of CHD.