线粒体通透性转换孔与老年心肌的研究进展

Mitochondrial permeability transition pore and aged myocardium: a systematic review

摘要:

随着人体的衰老进程，心肌细胞的结构、功能均会发生变化，这就使得老年心肌细胞对缺血缺氧等应激事件较年轻心肌细胞更为敏感，且耐受性差，因此，心血管疾病已经成为老年人群中最致命的杀手。线粒体通透性转换孔（mPTP）是一种非选择性的线粒体膜通道，mPTP的启闭在心肌细胞的保护中具有重要作用。在老年心肌中，对于mPTP开放的调节存在着一定的特殊性：一些抑制其开放的药物对年轻心肌具有保护作用，而对老年心肌保护作用却不明显。另外，mPTP的开放反过来也影响着细胞的衰老进程。因此，研究老年心肌的mPTP的结构和功能对提高老年人心血管疾病治疗水平有重要意义。

Abstract:

With the ageing process, structural and functional changes of myocardium occur, so the elderly become more sensible and vulnerable to hypoxic-ischemic damage than the young. Thus cardiovascular disease has already become the most deadly disease in the elderly, as well as a threat to their life quality. The mitochondrial permeability transition pore (mPTP) is a non-selective membrane channel, and the opening of mPTP leads to irreversible cell injury. Consequently, its opening regulation plays an important role in cardioprotection. Evidences indicated that the mPTP regulation of the aged myocardium is special. For example, cardioprotection drugs, which were effective to inhibit the opening of mPTP in the young, showed a decreased efficacy in the elderly. Moreover, it is noticed that the mPTP influences the aging process. Therefore, to improve diagnosis and treatment of cardiovascular disease in the elderly, further researches on the structure and function of mPTP in aged myocardium are essential.