内皮脂肪酶启动子-384A/C多态性与老年急性冠脉综合征及血脂的相关性

Association of endothelial lipase-384A/C gene polymorphism with acute coronary syndrome and blood lipids in Chinese elderly

摘要:

目的 探讨内皮脂肪酶基因启动子-384A/C基因多态性与老年急性冠脉综合征及血脂的相关性。方法 采用聚合酶链反应-限制性片段长度多态性方法检测241例老年急性冠脉综合征（ACS）患者和181例健康体检者内皮脂肪酶基因启动子-384A/C基因型。结果 中国常州地区汉族人群老年人存在EL-384A/C基因多态性，C等位基因频率为13.74%。对照组与老年ACS组EL-384A/C基因型和等位基因频率分布差异无统计学意义；经校正性别、年龄、糖尿病、高血压、吸烟、高脂血症等冠心病危险因素后，结果仍然表明该多态性与老年ACS无明显相关性。不同基因型亚组间血脂水平差异无统计学意义。结论 EL-384A/C基因多态性与老年ACS及血脂无明显相关性，该多态性可能不是中国常州地区汉族人群老年ACS发病的易感因素。

Abstract:

Objective To explore the potential relationship of EL-384 A/C gene polymorphism with acute coronary syndrome(ACS) and blood lipids in the eldelry. Methods The EL gene promoter-384A/C genotype in 241 aged ACS patients and 181 controls was detected by polymerase chain reaction-restriction fragment length polymorphism analysis. Results There was EL gene-384A/C polymorphism in elderly Chinese Han population in Changzhou region. The C allele frequency was 13.74%. There was no significant difference in the genotypes and allele frequencies of EL-384A/C between the controls and elderly ACS patients. After adjusting for the risk factors of coronary heart disease, including gender, age, diabetes mellitus, hypertension, smoking and hyperlipidemia, no association between EL-384 A/C gene polymorphism and ACS was observed in the elderly. Additionally, the levels of blood lipids were not significantly different between AA genotype and AC+CC genotype. Conclusion There is no significant association between EL gene-384A/C polymorphism and ACS and blood lipids in the elderly. This EL gene-384A/C polymorphism might not be involved in the pathogenesis of ACS in elderly Chinese Han population in Changzhou region.