Abstract:Objective To investigate the age-associated histological changes of fundic gland and ultrastructure of gastric parietal cells. Methods Fifty subjects with a relative normal stomach were enrolled including 19 cases in younger group (aged 20-59) and 31 cases in elder group (≥60 years) . In the elder group, there were 11 cases aged from 60 to 69, 10 cases from 70 to 79 and 10 cases aged above 80. The histology and morphology of fundic gland was observed under a light microscope, including the lamina propria thickness (from the epithelium to the muscularis mucosa, without the muscularis mucosa) and the Np/Na ratio (Np means the number of gastric parietal cell, Na means the number of all cells in fundic gland), and the ultrastructure of gastric parietal cells was detected by electron microscope. Results No significant difference was showed in the histology and morphology of fundic gland. The average ratio of Np to Na did not differ between younger group and elder group. However, the thickness of lamina propria in elderly group(892±172)μm was significantly lower than that in younger group(1014±203)μm ( P<0.05), while the average ratio Ap to Af (Ap means the area of parenchyma, Af means the area of high-power field) of elderly group (83±11)% was higher than that of younger group (80±7)% (P<0.05). Furthermore, no significant difference was showed in the morphology of gastric parietal cell and acid-secretion-associated organelles among all the groups. Both the average ratio of Am to Ac (Am means the area of mitochondria, Ac means the area of cytoplasm of gastric parietal cell) and At to Ac (At means the area of secretory canaliculi and tubulovesicular system) do not associated with aging as there was no statistically significant difference between two groups [(48 ± 8)% vs (51 ± 8)%, P>0.05; (14 ± 4)% vs (12 ± 5)%, P>0.05)]. Conclusion The histology and morphology of acid-secretion tissue have no significant degeneration in the elderly. The results provide a scientific basis to clarify the well acid secretory function in the elderly.