血管性认知功能障碍与饮茶──病例对照研究

Vascular cognitive impairment and tea-drinking: a case-control study

摘要:

目的 探讨血管性认知功能障碍与饮茶的关系。方法 采用分层、分段、随机、整群等距的抽样方法，2004年对抽取的北京市60岁以上老年人1865人进行调查。将87例血管性认知功能障碍患者纳入病例组，87名健康老年人纳入对照组，以性别和年龄为匹配条件进行病例对照研究，进行单因素分析及多因素Logistic分析（居住地区、文化程度、经济收入、高血压）。结果 交互分析发现饮茶且经济收入好的人群OR值（0.19）最小，其次为饮茶且文化程度高的人群（OR=0.204）。单因素分析发现病例组（23例）几乎每天饮茶的比例明显低于对照组（41例）（OR=0.347，P＝0.002）；随着饮茶频率的增加，OR值减小；两组间饮茶种类无明显差异。同时发现患高血压和经济收入低者在病例组中的比例高于对照组，差异有统计学意义（P<0.05）。多因素分析发现饮茶与血管性认知障碍存在负相关关系，与不饮茶者相比，几乎每天饮茶者患血管性认知功能障碍的OR值为0.513（P=0.039）。结论 饮茶可能是血管性认知功能障碍的保护因素。

Abstract:

Objective To explore the correlation between vascular cognitive impairment and tea-drinking. Methods A total of 1865 elder individuals aged over 60 years were sampled in 2004 in Beijing. We conducted a population based case-control study on 87 patients with vascular cognitive impairment (case group) and 87 sex- and age-matched controls（control group）. Univariate analysis was conducted firstly, and then multivariate analysis for financial situation，hypertension，tea drinking，education and living area was conducted using logistic model. Results In cross-link analysis, the ORs for tea drinkers who had better financial situation or a higher education level were the least (OR=0.190 and 0.204 respectively). In univariate analysis, tea drinkers in case group were less than those in controls (＝10.508, P＝0.015), and the ORs decreased as the decrease of frequency of tea-drinking. But there was no difference in the sorts of the tea. There were less individuals who had hypertension or worse financial situation in case group than in control group. In multivariate analysis, tea intake was associated with a lower prevalence of cognitive impairment. The OR was 0.513 for individuals who drink tea almost everyday, compared with non-tea-drinkers. Conclusion Tea-drinking may be the protective factor of vascular cognitive impairment.