轻度认知功能障碍向阿尔茨海默病转化的预测研究进展

Predictive study of conversion to Alzheimers disease in patients with mild cognitive impairment

摘要:

轻度认知功能障碍（MCI）是介于正常衰老与痴呆之间的认知功能缺损状态, MCI进展为阿尔茨海默病（AD）的危险性较高, 故MCI阶段可能是进行AD预防性治疗的最合适阶段, 因而成为研究的焦点。本文就近年来MCI向AD的转化预测研究做一综述, 主要包括五个方面: 神经心理学测试、生物标志物检查、神经影像学检查、脑电生理学检查及其治疗进展。

Abstract:

Mild cognitive impairment (MCI) has been described as a transitional state between the cognitive changes of normal aging and dementia, which has a higher risk of conversion to Alzheimer￠s diseases(AD). Therefore, MCI stage may be the most proper time to receive preventive therapy, and it has become the focus of studies. In this paper, we reviewed the recent progress of the neuropsychological testing, biomarker examination, neuroimaging examination, brain electrophysiological examination and treatment in the diagnosis of conversion from mild cognitive impairment to AD.