老年心房颤动患者的抗凝策略与抗凝强度评价

Anticoagulation strategy and anticoagulation intensity evaluation in elderly patients with atrial fibrillation

摘要:

房颤是一个严重的临床问题, 随着年龄增长, 其发病率逐渐增高。房颤所导致的血栓栓塞并发症高, 致死、致残率高, 未经治疗的房颤患者脑卒中年发生率平均为5%。在临床工作中, 年龄是房颤患者血栓栓塞危险分层及指导抗凝策略的重要因素, 对75岁以上、肾功能异常、高血压未能良好控制者在抗凝治疗中应加强监测, 可考虑适当降低抗凝强度, 以防止出血并发症。

Abstract:

Atrial fibrillation is a serious clinical problem and its incidence increases with age. Embolism caused by atrial fibrillation can lead to a lot of complications with high mortality and disability rate. One-year incidence of stroke in patients with atrial fibrillation who receive no therapy is 5%. In clinical practice, age is an important factor for risk stratification of embolism and guidance of anticoagulation in atrial fibrillation patients. Anticoagulation intensity should be decreased appropriately to prevent hemorrhage in patients who are ≥75 years old, have abnormal kidney function and/or poorly controlled blood pressure.