载脂蛋白A5基因多态性与甘油三酯及动脉粥样硬化性疾病的关系

Association of apolipoprotein A5 gene polymorphism with triglyceride and atherosclerosis disease

摘要:

载脂蛋白A5是一个新发现的载脂蛋白, 虽然血浆浓度很低, 但却能显著降低血浆甘油三酯的载脂蛋白, 其基因多态性与甘油三酯水平及动脉粥样硬化性疾病的关系密切。本文简要介绍了载脂蛋白A5的结构、功能、基因多态性及其与甘油三酯和动脉粥样硬化性疾病关系的研究进展。

Abstract:

Apolipoprotein A5 is a newly identified apolipoprotein. Although it is at low level in serum, it decreases plasma triglyceride level significantly. The gene polymorphism of apolipoprotein A5 is closely associated with plasma triglyceride level and atherosclerosis disease. We reviewed its structure, function and gene polymorphism, as well as its association with triglyceride and atherosclerosis disease.