骨质疏松与间充质干细胞

Osteoporosis and mesenchymal stem cell

摘要:

骨髓间充质干细胞（MSCs）具有自我更新和多向分化潜能, 在成年人的骨骼中它主要分化为成骨细胞和脂肪细胞。随着年龄增长, MSCs发生老化, 其细胞分化方向改变, 致使成骨细胞生成减少, 脂肪细胞生成增多, 这可能是骨质疏松（OP）的原因之一。通过移植健康的MSCs重建造骨能力, 将为OP的防治提供新的思路和方法。

Abstract:

Mesenchymal stem cells (MSCs), with high self-renewal capacity and muti-potentiality, are mainly differentiated into osteoblasts and adipocytes in adult bone marrow. With aging, MSCs senescence results in the differentiation shift: osteoblasts decline and adipocytes increase, which may account for the osteoporosis. The transplantation of healthy bone MSCs, which can rebuild osteogenesis ability, will provide a new idea for the prevention and treatment of osteoporosis.