Abstract:Objective To monitor the changes in plasma levels of brain natriuretic peptides(BNP),procalcitonin(PCT),monocyte human leukocyte antigen DR(HLA-DR) and acute physiology and chronic health evaluation(APACHE) Ⅲ score in elderly patients with septic shock,and to evaluate the clinical significance.Methods The above indices were measured before and at one week after resuscitation in 62 elderly patients with septic shock.Results At one week after resuscitation,the plasma levels of BNP,PCT,and APACHE Ⅲ score showed a significant decreasing tendency,and the expression of HLA-DR a significant increasing tendency in 8 patients(resuscitation successful group)(P<0.05).The plasma levels of BNP,PCT,and APACHE Ⅲ score showed a significant increasing tendency,and the expression of HLA-DR a significant decreasing tendency in 42 patients(resuscitation failure group).Twelve patients died(death group);among them,the level of plasma BNP reached more than 4000 ng/L in 3 patients and more than 3000 ng/L in 7 patients on the day of death.There was significant difference in plasma BNP level and APACHE Ⅲ score(P<0.05),and no difference in PCT and HLA-DR(P>0.05)among the 3 groups.Conclusion In elderly patients with septic shock,the higher plasma BNP level predicates poorer prognosis.Plasma BNP level might be an strong predicator for treatment effciency evaluation and prognosis of septic shock in the elderly patients.?更多