Abstract:Metabolic syndrome is a complexity of metabolic derangement with quite high and ever-rising prevalence. Its related diseases, such as obesity, insulin resistance, diabetes, hypertension, and dyslipidemia, all contribute to premature cardiovascular aging. Autophagy-lysosomal pathways represent the major cellular machineries for degradation and removal of damaged or long-lived proteins and organelles produced during the process of cardiovascular aging, and take part in the occurrence and development of premature cardiovascular aging which is associated with metabolic syndrome. To investigate new therapeutic avenue for premature cardiovascular aging under diversified metabolic abnormalities, it is of great importance to grasp the accurate role of autophagy in regulation of the process. In the article, we briefly review the integral role of autophagy in premature cardiovascular aging based on the present domestic and abroad researches at home and abroad in order to provide a new theoretical basis for delaying premature cardiovascular aging and improving the dysfunction of cardiovascular system.