抑郁情绪与血脂代谢交互作用对绝经后女性骨质疏松疾病的影响

Influence of interaction effect between depression and lipid metabolism on osteoporosis in postmenopausal women

【摘要】目的 调查抑郁情绪与血脂代谢交互作用对绝经后女性骨质疏松疾病的影响。方法 选择佛山复星禅诚医院2022年6月至2023年6月收治的510例绝经后女性为研究对象,筛查骨质疏松发生情况。采用SPSS 22.0统计软件进行数据分析。根据数据类型,采用χ²检验进行组间比较。采用二元logsitic回归模型分析影响绝经后女性发生骨质疏松的相关因素,并将抑郁情绪及血脂代谢紊乱作为2个交互项,调整混杂因素,评价抑郁情绪与血脂代谢紊乱交互作用对绝经后女性罹患骨质疏松的影响。结果 510例绝经后女性中有169例合并骨质疏松,占比33.14%。二元logistic回归分析提示,抑郁(OR=2.843,95%CI 1.366~5.918)及血脂代谢紊乱(OR=2.683,95%CI 1.660~4.337)是影响绝经后女性发生骨质疏松的独立危险因素。抑郁及血脂代谢紊乱具有相加交互作用,交互作用超额相对危险度(RERI)=1.151,95%CI 0.379~1.768；交互作用归因比(API)=0.425,95%CI 0.173~0.743；交互作用指数(SI)=2.264,95%CI 1.077~5.157。结论 抑郁及血脂代谢紊乱是绝经后女性发生骨质疏松的危险因素,且二者对绝经后女性骨质疏松具有相加交互作用。

基金项目:佛山市卫生健康局医学科研课题(20230816A010085)；广东省科技计划项目(2022B1212010011)

【Abstract】Objective To investigate the influence of interaction effect between depression and lipid metabolism on postmenopausal women with osteoporosis. Methods A total of 510 postmenopausal women admitted to our hospital from June 2022 to June 2023 were recruited, and the occurrence of osteoporosis was screened. SPSS statistics 22.0 was used for data analysis. Depending on data type, Chi-square test was performed for comparison between groups. Binary logistic regression analysis was applied to analyze the related factors affecting osteoporosis in the participants. After taking depression and dyslipidemia as two interaction factors and adjusting confounding factors, the influence of interaction effect between the two factors on osteoporosis in postmenopausal women was evaluated. Results Among the 510 participants, 169 of them (33.14%) had osteoporosis. Binary logistic regression analysis suggested that depression (OR=2.843,95%CI 1.366-5.918) and dyslipidemia (OR=2.683,95%CI 1.660-4.337) were independent risk factors for osteoporosis in post-menopausal women. There was an additive interaction effect between depression and dyslipidemia, with a relative excess risk of interaction (RERI) of 1.151 (95%CI 0.379-1.768), an attributable proportion of interaction (API) of 0.425 (95%CI 0.173-0.743) and a synergy index (SI) of 2.264 (95%CI 1.077-5.157). Conclusion Depression and dyslipidemia are risk factors for osteoporosis in postmenopausal women, and they have an additive interaction effect on osteoporosis in postmenopausal women.

This work was supported by the Medical Research Project of Foshan Health Bureau (20230816A010085) and the Project of Science andTechnology Plan of Guangdong Province (2022B1212010011).