【Abstract】Objective To explore the psychological resilience and quality of life (QOL) and their correlation in elderly patients with hemorrhagic stroke during intensive care unit (ICU)-rehabilitation transition period. Methods A total of 160 elderly patients with hemorrhagic stroke during the transition period from ICU to general ward in our hospital from January 2023 to August 2023 were enrolled as the research subjects. Their QOL was investigated by short-form 36-item health survey (SF-36), and the psychological resilience was evaluated by Chinese version of Connor-Davidson resilience scale (CD-RISC). SPSS statistics 19.0 was used for data analysis. Depending on the data type, analysis of variance, student′s t test or Chi-square test was performed for intergroup comparison. Multivariate linear regression model was adopted to analyze the related factors affecting the QOL of patients. Pearson correlation analysis was employed to assess the correlation between QOL and psychological resilience. Results Among the 160 questionnaires, 147 were valid, with an effective rate of 91.88%. The total score of SF-36 scale and score of CD-RISC scale were (464.47±56.07) and (45.38±13.74) points, respectively, in these elderly patients with hemorrhagic stroke during ICU-rehabilitation transition period points, and both were lower than the national norms (t=11.619,4.551; P<0.05). Pearson correlation analysis suggested that SF-36 score was positively correlated with CD-RISC score in the elderly patients (r=0.527; P<0.001). Multivariate linear regression analysis indicated that acute physiology and chronic health evaluationⅡ (APACHEⅡ) score at admission (β=-0.173; P=0.035), length of ICU stay (β=-0.355; P<0.001), mechanical ventilation (β=-0.276; P<0.001), ICU acquired weakness (ICU-AW) (β=-0.484; P<0.001), pain degree (β=-0.232; P<0.001), sleep disorder (β=-0.267; P<0.001) and anxiety (β=-0.191; P=0.016) were related factors affecting QOL, which jointly explained 42.50% of the variance in the QOL of patients (F=36.251; P<0.001). ConclusionThe QOL in elderly patients with hemorrhagic stroke during ICU-rehabilitation transition period is affected by disease condition at admission, ICU treatment factors, sleep disorder, anxiety and pain. Meanwhile, their psychological resilience is decreased. Active psychological resilience-related intervention has certain significance in improving their QOL.