氨基酸代谢在慢性阻塞性肺疾病中的研究进展

Research progress of amino acid metabolism in chronic obstructive pulmonary disease

【摘要】慢性阻塞性肺疾病(COPD)是一种复杂的异质性疾病,常合并多种肺外表现,包括营养不良及氨基酸代谢紊乱等。近年来,氨基酸代谢组学在COPD的发病机制、治疗及预后等方面得到广泛研究,因此,深入了解氨基酸代谢在COPD中的作用并探索氨基酸补充剂的应用,对COPD的系统性管理具有指导意义。因此,本文就氨基酸代谢在COPD中的作用进行综述。

基金项目:山西省基础研究计划项目(202303021221194)

【Abstract】Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, and it often merges with multiple extrapulmonary manifestations, including malnutrition and amino acid metabolism disorders. Recently, amino acid metabolomics has been extensively studied in the pathogenesis, treatment and prognosis of COPD. Thus,deeply understanding the role of amino acid metabolism in COPD and exploring the application of amino acid supplements are instructive for the systemic management of COPD. Therefore, this review addressed the role of amino acid metabolism in COPD.

This work was supported by the Fundamental Research Program of Shanxi Province (202303021221194) .