【Abstract】Objective To investigate the short-term quality of life in the elderly critically ill patients after liver cancer surgery and to analyze its influencing factors. Methods A retrospective analysis was made of the clinical data of 152 elderly critically ill patients admitted to intensive care unit after liver cancer surgery in the Affiliated Cancer Hospital of Xinjiang Medical University from February 2020 to March 2022. Before surgery and at three months after surgery, geriatric nutritional risk index (GNRI) was used to assess the nutritional risk of patients. At three months after surgery, quality of life with liver cancer (QOL-LCV2.0) was used to evaluate the short-term quality of life. Patients were classified into the good life-quality group (n=78) and poor life-quality group (n=74) according to the quality of life measured at three months after surgery. SPSS 24.0 was used for data analysis. According to the data type, Chi-square test or t test was used to compare the enumeration data between groups. Logistic regression analysis was used to evaluate the influencing factors of poor short-term quality of life in the elderly critically ill patients after liver cancer surgery. Results At three months after surgery, the total score on QOL-LCV2.0 of the elderly critically ill patients after liver cancer surgery was (124.89±9.22) points. Logistic regression analysis showed that age ≥ 70 years (OR=1.929,95%CI 1.011-4.290; P<0.05), preoperative GNRI≤ 98 (OR=3.593,95%CI 2.252-5.734; P<0.05), and postoperative complications (OR=2.550,95%CI 1.411-4.606; P<0.05) were risk factors for poor short-term quality of life in the elderly critically ill patients after liver cancer surgery. Conclusion The short-term quality of life in the elderly critically ill patients after liver cancer surgery is worthy of attention. Age, nutritional risk and postoperative complications are important factors affecting their short-term quality of life.