他汀类药物在临床应用中的主要不良反应及防治策略

Adverse effects of statins and prevention strategies in clinical application:a review

【摘要】他汀类药物作为心脑血管疾病的一线用药已经在临床中被广泛应用。随着使用人群的不断扩大及研究的不断深入,他汀类药物在骨骼肌、肝脏和肾脏的不良反应及其引发糖尿病的风险开始备受关注。本文旨在汇总有关他汀类药物临床应用的新近研究结果和相关基础研究,总结其主要不良反应及防治策略,为临床应用该类药物提供参考。

基金项目:北京市保健科研项目(京17-05)；北京市科委首都市民健康培育项目(Z171100000417055)；首都医科大学学生科研创新项目(XSKY2017139)

【Abstract】Statins have been widely used as a first-line drug therapy for cardiovascular and cerebrovascular diseases. The growing population on statins and number of related studies have raised greater concern about their risk of adverse effects on the skeletal muscles, liver and kidneys and its association with diabetes. In this review, we summarized the adverse effects of statins by exploring the literature available and propose prevention strategies, thus providing evidence for their clinical application.