血管生成素样蛋白2在动脉粥样硬化疾病中的作用

Role of angiopoietin-like protein 2 in atherosclerotic disease

【摘要】血管生成素样蛋白2(Angptl2)属于血管生成素样蛋白家族成员,其表达或分泌的节律性有助于维护组织内稳态,并且与冠心病、腹主动脉瘤、血管炎症和下肢动脉硬化性闭塞症密切相关。因此,对Angptl2的相关研究具有重要意义。本文对Angptl2在动脉粥样硬化疾病中的作用作一综述。

基金项目:内蒙古自然科学基金项目(2017MS0842)；内蒙古医科大学科技百万工程(联合)项目[YKD2016KJBW(LH)033]；内蒙古自治区人民医院院内基金项目(2016030)

【Abstract】Angiopoietin-like protein 2 (Angptl2) is a member of angiopoietin-like protein family, whose rhythmical expression or secretion helps maintaining body homeostasis, and is associated with coronary heart disease (CHD), abdominal aortic aneurysm (AAA), vascular inflammation and arteriosclerosis obliterians of lower extremity. Thus, it is of great significance for the studies concerning Angptl2. This article reviewed the role of Angptl2 in the pathogenesis of arteriosclerosis obliterians.